Polymerase Chain Reaction on Respiratory Tract Specimens of Immunocompromised Patients to Diagnose Pneumocystis Pneumonia: A Systematic Review and Meta-analysis

Resource type
Journal Article
Authors/contributors
Title
Polymerase Chain Reaction on Respiratory Tract Specimens of Immunocompromised Patients to Diagnose Pneumocystis Pneumonia: A Systematic Review and Meta-analysis
Abstract
This meta-analysis demonstrated very high diagnostic performance of PCR assays when used as screening tests for Pneumocystis pneumonia in high-risk patient groups, regardless of HIV status. qPCR on bronchoalveolar lavage fluid samples provided optimal sensitivity, closely followed by qPCR on induced sputum, while also providing adequate specificity., Graphical abstractThis graphical abstract is also available at Tidbit: https://tidbitapp.io/tidbits/pcr-on-respiratory-tract-specimens-of-immunocompromised-patients-to-diagnose-pneumocystosis-pcp-a-systematic-review-and-meta-analysis-89aa7a50-efbc-4ebb-8f20-c17d207e8d8e?utm_campaign=tidbitlinkshare&utm_source=ITP
Publication
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Volume
79
Issue
1
Pages
161-168
Date
2024-6-11
Journal Abbr
Clin Infect Dis
ISSN
1058-4838
Short Title
Polymerase Chain Reaction on Respiratory Tract Specimens of Immunocompromised Patients to Diagnose Pneumocystis Pneumonia
Accessed
9/3/24, 7:16 AM
Library Catalog
PubMed Central
Extra
PMID: 38860786 PMCID: PMC11259226
Citation
Brown, L., Rautemaa-Richardson, R., Mengoli, C., Alanio, A., Barnes, R. A., Bretagne, S., Chen, S. C. A., Cordonnier, C., Donnelly, J. P., Heinz, W. J., Jones, B., Klingspor, L., Loeffler, J., Rogers, T. R., Rowbotham, E., White, P. L., & Cruciani, M. (2024). Polymerase Chain Reaction on Respiratory Tract Specimens of Immunocompromised Patients to Diagnose Pneumocystis Pneumonia: A Systematic Review and Meta-analysis. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 79(1), 161–168. https://doi.org/10.1093/cid/ciae239
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