Concurrent JCPyV-DNAemia Is Correlated With Poor Graft Outcome in Kidney Transplant Recipients with Polyomavirus-associated Nephropathy
Resource type
Journal Article
Authors/contributors
- Zhang, Hui (Author)
- Luo, Jin-Quan (Author)
- Zhao, Guo-Dong (Author)
- Huang, Yang (Author)
- Yang, Shi-Cong (Author)
- Chen, Pei-Song (Author)
- Li, Jun (Author)
- Wu, Cheng-Lin (Author)
- Qiu, Jiang (Author)
- Chen, Xu-Tao (Author)
- Huang, Gang (Author)
Title
Concurrent JCPyV-DNAemia Is Correlated With Poor Graft Outcome in Kidney Transplant Recipients with Polyomavirus-associated Nephropathy
Abstract
Background.
Co-infection of JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV) is uncommon in kidney transplant recipients, and the prognosis is unclear. This study aimed to investigate the effect of concurrent JCPyV-DNAemia on graft outcomes in BKPyV-infected kidney transplant recipients with polyomavirus-associated nephropathy (PyVAN).
Methods.
A total of 140 kidney transplant recipients with BKPyV replication and PyVAN, 122 without concurrent JCPyV-DNAemia and 18 with JCPyV-DNAemia were included in the analysis. Least absolute shrinkage and selection operator regression analysis and multivariate Cox regression analysis were used to identify prognostic factors for graft survival. A nomogram for predicting graft survival was created and evaluated.
Results.
The median tubulitis score in the JCPyV-DNAemia-positive group was higher than in JCPyV-DNAemia-negative group (
P
= 0.048). At last follow-up, the graft loss rate in the JCPyV-DNAemia-positive group was higher than in the JCPyV-DNAemia-negative group (50% versus 25.4%;
P
= 0.031). Kaplan–Meier analysis showed that the graft survival rate in the JCPyV-DNAemia-positive group was lower than in the JCPyV-DNAemia-negative group (
P
= 0.003). Least absolute shrinkage and selection operator regression and multivariate Cox regression analysis demonstrated that concurrent JCPyV-DNAemia was an independent risk factor for graft survival (hazard ratio = 4.808; 95% confidence interval: 2.096-11.03;
P
< 0.001). The nomogram displayed favorable discrimination (C-index = 0.839), concordance, and clinical applicability in predicting graft survival.
Conclusions.
Concurrent JCPyV-DNAemia is associated with a worse graft outcome in BKPyV-infected kidney transplant recipients with PyVAN.
Publication
Transplantation
Date
2024-03-19
Language
en
ISSN
0041-1337
Accessed
4/28/24, 12:33 PM
Library Catalog
DOI.org (Crossref)
Citation
Zhang, H., Luo, J.-Q., Zhao, G.-D., Huang, Y., Yang, S.-C., Chen, P.-S., Li, J., Wu, C.-L., Qiu, J., Chen, X.-T., & Huang, G. (2024). Concurrent JCPyV-DNAemia Is Correlated With Poor Graft Outcome in Kidney Transplant Recipients with Polyomavirus-associated Nephropathy. Transplantation. https://doi.org/10.1097/TP.0000000000004995
ORGANISMS
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