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Information regarding COVID-19 continues to change rapidly. This document will be updated with new information whenever possible. Please contact your transplant center with specific questions or concerns. Human coronaviruses are common viruses that cause the common cold, and do not usually cause serious symptoms. A novel coronavirus named SARS-CoV-2 causes the disease called Coronavirus disease 2019 (COVID-19). This coronavirus appeared in December 2019 and quickly spread all over the world. COVID-19 spreads from person to person through close contact, most often by respiratory droplets that are spread when an infected person coughs, sneezes or talks. People are thought to be most contagious when they have symptoms, but even those who are not experiencing symptoms or have mild symptoms can also spread the virus. Like many other viruses, mutations are common with SARS-CoV-2 and several important variants have been reported since December 2019. In late 2021, Omicron emerged and became the dominant variant around the world within a few weeks largely because its mutations allowed the virus to be even more infectious. Omicron has also shown an ability to escape immunity from vaccines or prior COVID-19 infections, causing a high number of breakthrough infections in both immunocompromised and non-immunocompromised individuals. New variants and subvariants of SARS-CoV-2 are expected to emerge.