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Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia
Resource type
Journal Article
Authors/contributors
- Cornely, Oliver A. (Author)
- Maertens, Johan (Author)
- Winston, Drew J. (Author)
- Perfect, John (Author)
- Ullmann, Andrew J. (Author)
- Walsh, Thomas J. (Author)
- Helfgott, David (Author)
- Holowiecki, Jerzy (Author)
- Stockelberg, Dick (Author)
- Goh, Yeow-Tee (Author)
- Petrini, Mario (Author)
- Hardalo, Cathy (Author)
- Suresh, Ramachandran (Author)
- Angulo-Gonzalez, David (Author)
Title
Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia
Abstract
In this randomized trial of patients undergoing treatment for acute myelogenous leukemia or the myelodysplastic syndrome, prophylaxis with posaconazole resulted in fewer fungal infections and longer survival than did prophylaxis with fluconazole or itraconazole. The difference was primarily due to a lower rate of invasive aspergillosis in the posaconazole group.
Publication
New England Journal of Medicine
Date
January 25, 2007
Volume
356
Issue
4
Pages
348-359
Accessed
11/1/18, 11:20 AM
ISSN
0028-4793
Library Catalog
Taylor and Francis+NEJM
Extra
PMID: 17251531
Citation
Cornely, O. A., Maertens, J., Winston, D. J., Perfect, J., Ullmann, A. J., Walsh, T. J., Helfgott, D., Holowiecki, J., Stockelberg, D., Goh, Y.-T., Petrini, M., Hardalo, C., Suresh, R., & Angulo-Gonzalez, D. (2007). Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia. New England Journal of Medicine, 356(4), 348–359. https://doi.org/10.1056/NEJMoa061094
DRUGS AND THERAPIES
HEME-ONC AND CELLULAR THERAPIES
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