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Combination Antifungal Therapy for Invasive Aspergillosis Revisited
Resource type
Journal Article
Author/contributor
- Panackal, Anil A. (Author)
Title
Combination Antifungal Therapy for Invasive Aspergillosis Revisited
Abstract
Invasive aspergillosis (IA) causes significant morbidity and mortality among immunocompromised hosts. Combination therapy with mold-active triazoles and echinocandins has been used with the hope of improving outcomes over monotherapy, especially in the setting of refractory disease. Herein, I update our prior systematic review and meta-analysis on combination therapy for salvage IA in the context of the recently published randomized clinical trial of combination therapy for primary IA. Clinicians should consider combination antifungals for IA in refractory disease despite immune reconstitution when there are concerns for resistance or pharmacokinetic variability.
Publication
Medical mycology: open access
Date
2016
Volume
2
Issue
2
Journal Abbr
Med Mycol Open Access
Accessed
11/1/18, 3:51 PM
ISSN
2471-8521
Library Catalog
PubMed Central
Extra
PMID: 27441304
PMCID: PMC4948747
Citation
Panackal, A. A. (2016). Combination Antifungal Therapy for Invasive Aspergillosis Revisited. Medical Mycology: Open Access, 2(2). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948747/
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