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Immunosuppressive Drugs for Kidney Transplantation

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Resource type
Journal Article
Author/contributor
Title
Immunosuppressive Drugs for Kidney Transplantation
Abstract
The central issue in organ transplantation remains suppression of allograft rejection. Thus, development of immunosuppressive drugs is the key to successful allograft function. Immunosuppressive agents are used for induction (intense immunosuppression in the initial days after transplantation), maintenance, and reversal of established rejection. This review focuses on agents that are either approved or in phase 2 or phase 3 trials in kidney transplantation, but many issues covered here are applicable to all organ transplantation. I begin with a model of the alloimmune response to illustrate how these medications act. Three-Signal Model of Alloimmune Responses Alloimmune responses involve both naive and . . .
Publication
New England Journal of Medicine
Date
2004-12-23
Volume
351
Issue
26
Pages
2715-2729
DOI
10.1056/NEJMra033540
URL
https://doi.org/10.1056/NEJMra033540
Accessed
3/24/24, 5:52 PM
ISSN
0028-4793
Library Catalog
Taylor and Francis+NEJM
Extra
Publisher: Massachusetts Medical Society _eprint: https://doi.org/10.1056/NEJMra033540 PMID: 15616206
Citation
Halloran, P. F. (2004). Immunosuppressive Drugs for Kidney Transplantation. New England Journal of Medicine, 351(26), 2715–2729. https://doi.org/10.1056/NEJMra033540
CORE CURRICULUM
Link to this record
https://transplantid.net/EHVIY24P