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Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
Resource type
Journal Article
Authors/contributors
- Holbrook, Nolan R (Author)
- Klontz, Erik H (Author)
- Adams, Gordon C (Author)
- Schnittman, Samuel R (Author)
- Issa, Nicolas C (Author)
- Bond, Sheila A (Author)
- Branda, John A (Author)
- Lemieux, Jacob E (Author)
Title
Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
Abstract
We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4. The parasite was sequenced from an immunocompromised patient on prophylactic atovaquone for Pneumocystis pneumonia before diagnosis of babesiosis.
Publication
Open Forum Infectious Diseases
Date
2023-03-01
Volume
10
Issue
3
Pages
ofad097
Journal Abbr
Open Forum Infectious Diseases
Accessed
4/2/23, 4:05 PM
ISSN
2328-8957
Library Catalog
Silverchair
Citation
Holbrook, N. R., Klontz, E. H., Adams, G. C., Schnittman, S. R., Issa, N. C., Bond, S. A., Branda, J. A., & Lemieux, J. E. (2023). Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis. Open Forum Infectious Diseases, 10(3), ofad097. https://doi.org/10.1093/ofid/ofad097
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