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Fatal Human Rabies Infection with Suspected Host-mediated Failure of Post-Exposure Prophylaxis Following a Recognized Zoonotic Exposure—Minnesota, 2021
Resource type
Journal Article
Authors/contributors
- Holzbauer, Stacy M (Author)
- Schrodt, Caroline A (Author)
- Prabhu, Rajesh M (Author)
- Asch-Kendrick, Rebecca J (Author)
- Ireland, Malia (Author)
- Klumb, Carrie (Author)
- Firestone, Melanie J (Author)
- Liu, Gongping (Author)
- Harry, Katie (Author)
- Ritter, Jana M (Author)
- Levine, Min Z (Author)
- Orciari, Lillian A (Author)
- Wilkins, Kimberly (Author)
- Yager, Pamela (Author)
- Gigante, Crystal M (Author)
- Ellison, James A (Author)
- Zhao, Hui (Author)
- Niezgoda, Michael (Author)
- Li, Yu (Author)
- Levis, Robin (Author)
- Scott, Dorothy (Author)
- Satheshkumar, Panayampalli S (Author)
- Petersen, Brett W (Author)
- Rao, Agam K (Author)
- Bell, W Robert (Author)
- Bjerk, Sonja M (Author)
- Forrest, Sara (Author)
- Gao, Wangcai (Author)
- Dasheiff, Richard (Author)
- Russell, Kari (Author)
- Pappas, Melissa (Author)
- Kiefer, Jessica (Author)
- Bickler, Wesley (Author)
- Wiseman, Anthony (Author)
- Jurantee, Joel (Author)
- Reichard, R Ross (Author)
- Smith, Kirk E (Author)
- Lynfield, Ruth (Author)
- Scheftel, Joni (Author)
- Wallace, Ryan M (Author)
- Bonwitt, Jesse (Author)
Title
Fatal Human Rabies Infection with Suspected Host-mediated Failure of Post-Exposure Prophylaxis Following a Recognized Zoonotic Exposure—Minnesota, 2021
Abstract
Conclusion: This is the first reported failure of rabies PEP in the Western Hemisphere using a cell culture vaccine. Host-mediated primary vaccine failure attributed to previously unrecognized D impaired immunity is the most likely explanation for this breakthrough infection. Clinicians should consider measuring rabies neutralizing antibody titers after completion of PEP if there is E any suspicion for immunocompromise.
Publication
Clinical Infectious Diseases
Date
2023-03-29
Pages
ciad098
Accessed
4/12/23, 6:52 AM
ISSN
1058-4838, 1537-6591
Language
en
Library Catalog
DOI.org (Crossref)
Citation
Holzbauer, S. M., Schrodt, C. A., Prabhu, R. M., Asch-Kendrick, R. J., Ireland, M., Klumb, C., Firestone, M. J., Liu, G., Harry, K., Ritter, J. M., Levine, M. Z., Orciari, L. A., Wilkins, K., Yager, P., Gigante, C. M., Ellison, J. A., Zhao, H., Niezgoda, M., Li, Y., … Bonwitt, J. (2023). Fatal Human Rabies Infection with Suspected Host-mediated Failure of Post-Exposure Prophylaxis Following a Recognized Zoonotic Exposure—Minnesota, 2021. Clinical Infectious Diseases, ciad098. https://doi.org/10.1093/cid/ciad098
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